Vitamine D

1. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease_Holick AJCN 2004

https://pubmed.ncbi.nlm.nih.gov/15585788/

2. Webb AR. Who, what, where and when-influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol. 2006 Sep;92(1):17-25. doi: 10.1016/j.pbiomolbio.2006.02.004. PMID: 16766240.

https://pubmed.ncbi.nlm.nih.gov/16766240/

3. Kimlin MG. Geographic location and vitamin D synthesis. Mol Aspects Med. 2008 Dec;29(6):453-61. doi: 10.1016/j.mam.2008.08.005. Epub 2008 Aug 28. PMID: 18786559.

https://pubmed.ncbi.nlm.nih.gov/18786559/

4. Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005 Jul;289(1):F8-28. doi: 10.1152/ajprenal.00336.2004. PMID: 15951480.

https://pubmed.ncbi.nlm.nih.gov/15951480/

5. Tuohimaa P. Vitamin D and aging. J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):78-84. doi: 10.1016/j.jsbmb.2008.12.020. PMID: 19444937.

https://pubmed.ncbi.nlm.nih.gov/19444937/

6. Norman AW, Bouillon R. Vitamin D nutritional policy needs a vision for the future. Exp Biol Med (Maywood). 2010 Sep;235(9):1034-45. doi: 10.1258/ebm.2010.010014. Epub 2010 Jul 28. PMID: 20667908.

https://pubmed.ncbi.nlm.nih.gov/20667908/

7. Holick, M. F. (2010). The vitamin D deficiency pandemic: a forgotten hormone important for health. Public health reviews, 32, 267-283.

https://link.springer.com/article/10.1007/BF03391602

8. Hossein-nezhad A, Spira A, Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PLoS One. 2013;8(3):e58725. doi: 10.1371/journal.pone.0058725. Epub 2013 Mar 20. PMID: 23527013; PMCID: PMC3604145.

https://pubmed.ncbi.nlm.nih.gov/23527013/

9. Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014 May;14(5):342-57. doi: 10.1038/nrc3691. Epub 2014 Apr 4. PMID: 24705652.

https://pubmed.ncbi.nlm.nih.gov/24705652/

10. Gröschel C, Tennakoon S, Kállay E. Cytochrome P450 Vitamin D Hydroxylases in Inflammation and Cancer. Adv Pharmacol. 2015;74:413-58. doi: 10.1016/bs.apha.2015.03.002. Epub 2015 May 11. PMID: 26233913.

https://pubmed.ncbi.nlm.nih.gov/26233913/

11. Wielders JP, Muskiet FA, van de Wiel A. Nieuw licht op vitamine D [Shedding new light on vitamin D--reassessment of an essential prohormone]. Ned Tijdschr Geneeskd. 2010;154:A1810. Dutch. PMID: 21176256.

https://pubmed.ncbi.nlm.nih.gov/21176256/

12. Rhodes JM, Subramanian S, Laird E, Griffin G, Kenny RA. Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis. J Intern Med. 2021 Jan;289(1):97-115. doi: 10.1111/joim.13149. Epub 2020 Jul 22. PMID: 32613681; PMCID: PMC7361294.

https://pubmed.ncbi.nlm.nih.gov/32613681/

13. Charoenngam N, Holick MF. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients. 2020 Jul 15;12(7):2097. doi: 10.3390/nu12072097. PMID: 32679784; PMCID: PMC7400911.

https://pubmed.ncbi.nlm.nih.gov/32679784/

Vitamin D toxicity in the press

14. Oudere persoon overleden na overdosis vitamine D, FAGG waarschuwt voor inname te hoge concentratie. VRT nieuws, Gezondheid. Laurens Dekock, Belga, 17 maart 2023. Accessed 20 March 2023

https://www.vrt.be/vrtnws/nl/2023/03/17/oudere-overleden-overdosis-vitam....

15. Flash Vig-News - Medicatiefout: opgepast voor specialiteiten met hoge concentraties aan vitamine D of vitamine D derivaten. FAGG, federaal agentschap voor geneesmiddelen en gezondheidsproducten. 17 March 2023, accessed 20 March 2023

https://www.fagg-afmps.be/nl/news/flash_vig_news_medicatiefout_opgepast_...

16. Oudere sterft aan overdosis vitamine D, toxicoloog waarschuwt: “Je kan het niet merken aan iemands gedrag, dat is gevaarlijk”. Nieuwsblad. Christoph Meeussen, Vrijdag 17 maart 2023, accessed 20 March 2023

https://www.nieuwsblad.be/cnt/dmf20230317_93866659

Skepticism regarding supplements

17. Ames BN, McCann JC, Stampfer MJ, Willett WC. Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough. Am J Clin Nutr. 2007 Aug;86(2):522-3; author reply 523-4. doi: 10.1093/ajcn/86.2.522. PMID: 17684228.

https://pubmed.ncbi.nlm.nih.gov/17684228/

18. Frei B, Ames BN, Blumberg JB, Willett WC. Enough is enough. Ann Intern Med. 2014 Jun 3;160(11):807. doi: 10.7326/L14-5011. PMID: 24887621.

https://pubmed.ncbi.nlm.nih.gov/24887621/

19. LeBoff MS, Chou SH, Ratliff KA, Cook NR, Khurana B, Kim E, Cawthon PM, Bauer DC, Black D, Gallagher JC, Lee IM, Buring JE, Manson JE. Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. N Engl J Med. 2022 Jul 28;387(4):299-309. doi: 10.1056/NEJMoa2202106. PMID: 35939577; PMCID: PMC9716639.

https://pubmed.ncbi.nlm.nih.gov/35939577/

20. Cummings SR, Rosen C. VITAL Findings - A Decisive Verdict on Vitamin D Supplementation. N Engl J Med. 2022 Jul 28;387(4):368-370. doi: 10.1056/NEJMe2205993. PMID: 35939583.

https://pubmed.ncbi.nlm.nih.gov/35939583/

21. Levi M. De inname van extra vitamines is volstrekt nutteloos. Het Parool 26 November 2022, accessed 14 December 2022

https://www.parool.nl/columns-opinie/de-inname-van-extra-vitamines-is-vo...

High dose monthly and yearly vitamin D trials with more falls

22. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC: Annual high-dose oral vitamin D and falls and fractures in older women. A randomized controlled trial. JAMA 2010, 303:1815–1822.

https://pubmed.ncbi.nlm.nih.gov/20460620/

23. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, Dick W, Willett WC, Egli A. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016 Feb;176(2):175-83. doi: 10.1001/jamainternmed.2015.7148. PMID: 26747333.

https://pubmed.ncbi.nlm.nih.gov/26747333/

24. Dawson-Hughes B, Harris SS. High-dose vitamin D supplementation: too much of a good thing? JAMA. 2010 May 12;303(18):1861-2. doi: 10.1001/jama.2010.598. PMID: 20460627.

https://pubmed.ncbi.nlm.nih.gov/20460627/

25. Owens DJ, Tang JC, Bradley WJ, Sparks AS, Fraser WD, Morton JP, Close GL. Efficacy of High-Dose Vitamin D Supplements for Elite Athletes. Med Sci Sports Exerc. 2017 Feb;49(2):349-356. doi: 10.1249/MSS.0000000000001105. PMID: 27741217.

https://pubmed.ncbi.nlm.nih.gov/27741217/

New functions of vitamin D

26. Hollis BW, Wagner CL. Clinical review: The role of the parent compound vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes. J Clin Endocrinol Metab. 2013 Dec;98(12):4619-28. doi: 10.1210/jc.2013-2653. Epub 2013 Oct 8. PMID: 24106283; PMCID: PMC3849670.

https://pubmed.ncbi.nlm.nih.gov/24106283/

27. Gibson CC, Davis CT, Zhu W, Bowman-Kirigin JA, Walker AE, Tai Z, Thomas KR, Donato AJ, Lesniewski LA, Li DY. Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium. PLoS One. 2015 Oct 15;10(10):e0140370. doi: 10.1371/journal.pone.0140370. PMID: 26469335; PMCID: PMC4607301.

https://pubmed.ncbi.nlm.nih.gov/26469335/

28. Bikle DD, Schwartz J. Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne). 2019 May 28;10:317. doi: 10.3389/fendo.2019.00317. PMID: 31191450; PMCID: PMC6546814.

https://pubmed.ncbi.nlm.nih.gov/31191450/

29. Mason RS, Rybchyn MS, Abboud M, Brennan-Speranza TC, Fraser DR. The Role of Skeletal Muscle in Maintaining Vitamin D Status in Winter. Curr Dev Nutr. 2019 Jul 25;3(10):nzz087. doi: 10.1093/cdn/nzz087. PMID: 31598576; PMCID: PMC6776467.

https://pubmed.ncbi.nlm.nih.gov/31598576/

Vitamin D ‘dietary reference intakes’ in The Netherlands

30. Gezondheidsraad, 2012. Evaluatie van de voedingsnormen voor vitamine D. Accessed 20 March 2023

https://www.gezondheidsraad.nl/documenten/adviezen/2012/09/26/evaluatie-...

31. Gezondheidsraad 2018. Voedingsnormen voor vitamines en mineralen voor volwassenen. Accessed 20 March 2023

https://www.gezondheidsraad.nl/documenten/adviezen/2018/09/18/gezondheid...

32. Voedingscentrum. Vitamine D. Accessed 20 March 2023.

https://www.voedingscentrum.nl/encyclopedie/vitamine-d.aspx

33. van Grootheest G, Milaneschi Y, Lips PT, Heijboer AC, Smit JH, Penninx BW. Determinants of plasma 25-hydroxyvitamin D levels in healthy adults in the Netherlands. Neth J Med. 2014 Dec;72(10):533-40. PMID: 26219759.

https://pubmed.ncbi.nlm.nih.gov/26219759/

UVA/AVB, vitamin D, skin cancer

33a. Sola Y, Lorente J. Contribution of UVA irradiance to the erythema and photoaging effects in solar and sunbed exposures. J Photochem Photobiol B. 2015 Feb;143:5-11. doi: 10.1016/j.jphotobiol.2014.10.024. Epub 2014 Dec 29. PMID: 25579807.

https://pubmed.ncbi.nlm.nih.gov/25579807/

33b. Cicarma E, Porojnicu AC, Lagunova Z, Dahlback A, Juzeniene A, Moan J. Sun and sun beds: inducers of vitamin D and skin cancer. Anticancer Res. 2009 Sep;29(9):3495-500. PMID: 19667143.

https://pubmed.ncbi.nlm.nih.gov/19667143/

33c. Holick MF. The cutaneous photosynthesis of previtamin D3: a unique photoendocrine system. J Invest Dermatol. 1981 Jul;77(1):51-8. doi: 10.1111/1523-1747.ep12479237. PMID: 6265564.

https://pubmed.ncbi.nlm.nih.gov/6265564/

33d. Webb AR. Who, what, where and when-influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol. 2006 Sep;92(1):17-25. doi: 10.1016/j.pbiomolbio.2006.02.004. PMID: 16766240.

https://pubmed.ncbi.nlm.nih.gov/16766240/

33e. Kimlin MG. Geographic location and vitamin D synthesis. Mol Aspects Med. 2008 Dec;29(6):453-61. doi: 10.1016/j.mam.2008.08.005. Epub 2008 Aug 28. PMID: 18786559.

https://pubmed.ncbi.nlm.nih.gov/18786559/

33f. Godar DE. Worldwide increasing incidences of cutaneous malignant melanoma. J Skin Cancer. 2011;2011:858425. doi: 10.1155/2011/858425. Epub 2011 Oct 10. PMID: 22007306; PMCID: PMC3191827.

https://pubmed.ncbi.nlm.nih.gov/22007306/

33g. Gilchrest BA. Sun protection and Vitamin D: three dimensions of obfuscation. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):655-63. doi: 10.1016/j.jsbmb.2006.12.028. Epub 2007 Jan 11. PMID: 17222550.

https://pubmed.ncbi.nlm.nih.gov/17222550/

33h. Godar DE. Worldwide increasing incidences of cutaneous malignant melanoma. J Skin Cancer. 2011;2011:858425. doi: 10.1155/2011/858425. Epub 2011 Oct 10. PMID: 22007306; PMCID: PMC3191827.

https://pubmed.ncbi.nlm.nih.gov/22007306/

33i. Godar DE, Subramanian M, Merrill SJ. Cutaneous malignant melanoma incidences analyzed worldwide by ex, age, and skin type over personal Ultraviolet-B dose shows no role for sunburn but implies one for Vitamin D3. Dermatoendocrinol. 2016 Dec 14;9(1):e1267077. doi: 10.1080/19381980.2016.1267077. PMID: 28924456; PMCID: PMC5400110.

https://pubmed.ncbi.nlm.nih.gov/28924456/

Vitamin D from sunlight.

34. Gilchrest BA. Sun protection and Vitamin D: three dimensions of obfuscation. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):655-63. doi: 10.1016/j.jsbmb.2006.12.028. Epub 2007 Jan 11. PMID: 17222550.

https://pubmed.ncbi.nlm.nih.gov/17222550/

35. Holick MF. Vitamin D: a d-lightful solution for health. J Investig Med. 2011 Aug;59(6):872-80. doi: 10.2310/JIM.0b013e318214ea2d. PMID: 21415774; PMCID: PMC3738435.

https://pubmed.ncbi.nlm.nih.gov/21415774/

36. Chen TC, Chimeh F, Lu Z, Mathieu J, Person KS, Zhang A, Kohn N, Martinello S, Berkowitz R, Holick MF. Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Biochem Biophys. 2007 Apr 15;460(2):213-7. doi: 10.1016/j.abb.2006.12.017. Epub 2007 Jan 8. PMID: 17254541; PMCID: PMC2698590.

https://pubmed.ncbi.nlm.nih.gov/17254541/

Arguments for higher vitamin D ‘dietary reference intakes’

37. Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr. 2003 May;89(5):552-72. doi: 10.1079/BJN2003837. PMID: 12720576.

https://pubmed.ncbi.nlm.nih.gov/12720576/

37a. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005 Jul;16(7):713-6. doi: 10.1007/s00198-005-1867-7. Epub 2005 Mar 18. PMID: 15776217.

https://pubmed.ncbi.nlm.nih.gov/15776217/

38. Muskiet FAJ, Van der Veer E. Vitamine D: waar liggen de grenzen van deficiëntie, adequate status en toxiciteit? Ned Tijdschr Klin Chem Labgeneesk 2007; 32: 150-158

https://www.nvkc.nl/sites/default/files/NTKC/2007-3-p150-158.pdf

39. Souberbielle JC, Body JJ, Lappe JM, Plebani M, Shoenfeld Y, Wang TJ, Bischoff-Ferrari HA, Cavalier E, Ebeling PR, Fardellone P, Gandini S, Gruson D, Guérin AP, Heickendorff L, Hollis BW, Ish-Shalom S, Jean G, von Landenberg P, Largura A, Olsson T, Pierrot-Deseilligny C, Pilz S, Tincani A, Valcour A, Zittermann A. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmun Rev. 2010 Sep;9(11):709-15. doi: 10.1016/j.autrev.2010.06.009. Epub 2010 Jul 1. PMID: 20601202.

https://pubmed.ncbi.nlm.nih.gov/20601202/

40. Sharma S, Barr AB, Macdonald HM, Sheehy T, Novotny R, Corriveau A. Vitamin D deficiency and disease risk among aboriginal Arctic populations. Nutr Rev. 2011 Aug;69(8):468-78. doi: 10.1111/j.1753-4887.2011.00406.x. PMID: 21790613.

https://pubmed.ncbi.nlm.nih.gov/21790613/

41. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6. Erratum in: J Clin Endocrinol Metab. 2011 Dec;96(12):3908. PMID: 21646368.

https://pubmed.ncbi.nlm.nih.gov/21646368/

42. Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc. 2013 Jul;88(7):720-55. doi: 10.1016/j.mayocp.2013.05.011. Epub 2013 Jun 18. PMID: 23790560; PMCID: PMC3761874.

https://pubmed.ncbi.nlm.nih.gov/23790560/

43. Muskiet FAJ, Schuitemaker GE, Van der Veer E, Wielders JPM. Een kritische beschouwing van de aanbevelingen en de rationale van het Gezondheidsraad rapport ‘Evaluatie van de voedingsnormen voor vitamine D’. Ned Tijdschr Klin Chem Labgeneesk 2013; 38: 169-185

https://www.allesovervitamined.nl/wp-content/uploads/2021/07/Een-kritisc...

44. Singh P, Kumar M, Al Khodor S. Vitamin D Deficiency in the Gulf Cooperation Council: Exploring the Triad of Genetic Predisposition, the Gut Microbiome and the Immune System. Front Immunol. 2019 May 10;10:1042. doi: 10.3389/fimmu.2019.01042. PMID: 31134092; PMCID: PMC6524467.

https://pubmed.ncbi.nlm.nih.gov/31134092/

45. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020 Apr 2;12(4):988. doi: 10.3390/nu12040988. PMID: 32252338; PMCID: PMC7231123.

https://pubmed.ncbi.nlm.nih.gov/32252338/

Arguments against higher vitamin D ‘dietary reference intakes’

46. Weggemans RM, Schaafsma G, Kromhout D. Towards an adequate intake of vitamin D. An advisory report of the Health Council of the Netherlands. Eur J Clin Nutr. 2009 Dec;63(12):1455-7. doi: 10.1038/ejcn.2009.67. Epub 2009 Jul 22. PMID: 19623202.

https://pubmed.ncbi.nlm.nih.gov/19623202/

Scientific evidence in medicine and nutrition

47. HILL AB. THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION? Proc R Soc Med. 1965 May;58(5):295-300. PMID: 14283879; PMCID: PMC1898525.

https://pubmed.ncbi.nlm.nih.gov/14283879/

48. How strong is the evidence that solar ultraviolet B and vitamin D reduce the risk of cancer?

https://pubmed.ncbi.nlm.nih.gov/23094927/

48a. Cohen AM, Hersh WR. Criticisms of evidence-based medicine. Evid Based Cardiovasc Med. 2004 Sep;8(3):197-8. doi: 10.1016/j.ebcm.2004.06.036. PMID: 16379931.

https://pubmed.ncbi.nlm.nih.gov/16379931/

48b. Tonelli MR. Integrating evidence into clinical practice: an alternative to evidence-based approaches. J Eval Clin Pract. 2006 Jun;12(3):248-56. doi: 10.1111/j.1365-2753.2004.00551.x. PMID: 16722902.

https://pubmed.ncbi.nlm.nih.gov/16722902/

48c. Martini, C. What “Evidence” in Evidence-Based Medicine?. Topoi 40, 299–305 (2021). https://doi.org/10.1007/s11245-020-09703-4

https://link.springer.com/article/10.1007/s11245-020-09703-4

48d. Fernandez A, Sturmberg J, Lukersmith S, Madden R, Torkfar G, Colagiuri R, Salvador-Carulla L. Evidence-based medicine: is it a bridge too far? Health Res Policy Syst. 2015 Nov 6;13:66. doi: 10.1186/s12961-015-0057-0. PMID: 26546273; PMCID: PMC4636779.

https://pubmed.ncbi.nlm.nih.gov/26546273/

48e. Tebala GD. The Emperor's New Clothes: a Critical Appraisal of Evidence-based Medicine. Int J Med Sci. 2018 Sep 7;15(12):1397-1405. doi: 10.7150/ijms.25869. PMID: 30275768; PMCID: PMC6158662.

https://pubmed.ncbi.nlm.nih.gov/30275768/

49. Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS. Evidence based medicine: what it is and what it isn't. BMJ. 1996 Jan 13;312(7023):71-2. doi: 10.1136/bmj.312.7023.71. PMID: 8555924; PMCID: PMC2349778.

https://pubmed.ncbi.nlm.nih.gov/8555924/

50. Argument from ignorance. Wikipedia, accessed 20 March 2023.

https://simple.wikipedia.org/wiki/Argument_from_ignorance

51. Voorzorgsprincipe. Wikipedia, accessed 20 March 2023.

https://nl.wikipedia.org/wiki/Voorzorgsprincipe

52. Luxwolda MF, Kuipers RS, Kema IP, Dijck-Brouwer DA, Muskiet FA. Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l. Br J Nutr. 2012 Nov 14;108(9):1557-61. doi: 10.1017/S0007114511007161. Epub 2012 Jan 23. PMID: 22264449.

https://pubmed.ncbi.nlm.nih.gov/22264449/

53. Luxwolda MF, Kuipers RS, Kema IP, van der Veer E, Dijck-Brouwer DA, Muskiet FA. Vitamin D status indicators in indigenous populations in East Africa. Eur J Nutr. 2013 Apr;52(3):1115-25. doi: 10.1007/s00394-012-0421-6. Epub 2012 Aug 10. PMID: 22878781.

https://pubmed.ncbi.nlm.nih.gov/22878781/

Vitamin D toxicity cases and pharmacokinetics

54. Kaptein S, Risselada AJ, Boerma EC, Egbers PH, Nieboer P. Life-threatening complications of vitamin D intoxication due to over-the-counter supplements. Clin Toxicol (Phila). 2010 Jun;48(5):460-2. doi: 10.3109/15563650.2010.486382. PMID: 20515399.

https://pubmed.ncbi.nlm.nih.gov/20515399/

54a. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med. 2001 Jul 5;345(1):66-7. doi: 10.1056/NEJM200107053450115. PMID: 11439958.

https://pubmed.ncbi.nlm.nih.gov/11439958/

55. Lowe H, Cusano NE, Binkley N, Blaner WS, Bilezikian JP. Vitamin D toxicity due to a commonly available "over the counter" remedy from the Dominican Republic. J Clin Endocrinol Metab. 2011 Feb;96(2):291-5. doi: 10.1210/jc.2010-1999. Epub 2010 Dec 1. PMID: 21123442.

https://pubmed.ncbi.nlm.nih.gov/21123442/

56. van den Ouweland J, Fleuren H, Drabbe M, Vollaard H. Pharmacokinetics and safety issues of an accidental overdose of 2,000,000 IU of vitamin D3 in two nursing home patients: a case report. BMC Pharmacol Toxicol. 2014 Sep 30;15:57. doi: 10.1186/2050-6511-15-57. PMID: 25269374; PMCID: PMC4185191.

https://pubmed.ncbi.nlm.nih.gov/25269374/

56a. Ilahi M, Armas LA, Heaney RP. Pharmacokinetics of a single, large dose of cholecalciferol. Am J Clin Nutr. 2008 Mar;87(3):688-91. doi: 10.1093/ajcn/87.3.688. PMID: 18326608.

https://pubmed.ncbi.nlm.nih.gov/18326608/

Vitamin D toxicity

56b. Taylor PN, Davies JS. A review of the growing risk of vitamin D toxicity from inappropriate practice. Br J Clin Pharmacol. 2018 Jun;84(6):1121-1127. doi: 10.1111/bcp.13573. Epub 2018 Apr 16. PMID: 29498758; PMCID: PMC5980613.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980613/

56c. Rijksinstituut voor Volksgezondheid en Milieu, Ministerie van Volksgezondheid, Welzijn en Sport. Nederlands Voedingsstoffenbestand (NEVO Tabellen), accessed 26 march 2023

https://nevo-online.rivm.nl/

57. Vieth R. Vitamin D and cancer mini-symposium: the risk of additional vitamin D. Ann Epidemiol. 2009 Jul;19(7):441-5. doi: 10.1016/j.annepidem.2009.01.009. Epub 2009 Apr 11. PMID: 19364661.

https://pubmed.ncbi.nlm.nih.gov/19364661/

57a. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999 May;69(5):842-56. doi: 10.1093/ajcn/69.5.842. PMID: 10232622.

https://pubmed.ncbi.nlm.nih.gov/10232622/

58. Nguyen T, Joe D, Shah AD. Forget the phosphorus: A case of hypervitaminosis D-induced symptomatic hypercalcemia. Clin Nephrol Case Stud. 2021 Feb 9;9:1-3. doi: 10.5414/CNCS110414. PMID: 33614397; PMCID: PMC7890937.

https://pubmed.ncbi.nlm.nih.gov/33614397/

59. Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. Front Endocrinol (Lausanne). 2018 Sep 20;9:550. doi: 10.3389/fendo.2018.00550. PMID: 30294301; PMCID: PMC6158375.

https://pubmed.ncbi.nlm.nih.gov/30294301/

60. Lim K, Thadhani R. Vitamin D Toxicity. J Bras Nefrol. 2020 Apr 3;42(2):238-244. doi: 10.1590/2175-8239-JBN-2019-0192. PMID: 32255467; PMCID: PMC7427646.

https://pubmed.ncbi.nlm.nih.gov/32255467/

61. Friedman WF, Roberts WC. Vitamin D and the supravalvar aortic stenosis syndrome. The transplacental effects of vitamin D on the aorta of the rabbit. Circulation. 1966 Jul;34(1):77-86. doi: 10.1161/01.cir.34.1.77. PMID: 5949492.

https://pubmed.ncbi.nlm.nih.gov/5949492/

62. DiPalma JR, Ritchie DM. Vitamin toxicity. Annu Rev Pharmacol Toxicol. 1977;17:133-48. doi: 10.1146/annurev.pa.17.040177.001025. PMID: 326160.

https://pubmed.ncbi.nlm.nih.gov/326160/

62a. Chan GM, Buchino JJ, Mehlhorn D, Bove KE, Steichen JJ, Tsang RC. Effect of vitamin D on pregnant rabbits and their offspring. Pediatr Res. 1979 Feb;13(2):121-6. doi: 10.1203/00006450-197902000-00007. PMID: 311915.

https://pubmed.ncbi.nlm.nih.gov/311915/

63. Schlingmann KP, Kaufmann M, Weber S, Irwin A, Goos C, John U, Misselwitz J, Klaus G, Kuwertz-Bröking E, Fehrenbach H, Wingen AM, Güran T, Hoenderop JG, Bindels RJ, Prosser DE, Jones G, Konrad M. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N Engl J Med. 2011 Aug 4;365(5):410-21. doi: 10.1056/NEJMoa1103864. Epub 2011 Jun 15. PMID: 21675912.

https://pubmed.ncbi.nlm.nih.gov/21675912/

64. Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin Nutr. 2007 Jan;85(1):6-18. doi: 10.1093/ajcn/85.1.6. PMID: 17209171.

https://pubmed.ncbi.nlm.nih.gov/17209171/

65. Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr. 2008 Aug;88(2):582S-586S. doi: 10.1093/ajcn/88.2.582S. PMID: 18689406.

https://pubmed.ncbi.nlm.nih.gov/18689406/

Poisoning data of the government

66. Gummin, D. D., Mowry, J. B., Beuhler, M. C., Spyker, D. A., Bronstein, A. C., Rivers, L. J., ... & Weber, J. (2021). 2020 Annual report of the American association of poison control centers’ national poison data system (NPDS): 38th annual report. Clinical toxicology, 59(12), 1282-1501.

https://www.tandfonline.com/doi/abs/10.1080/15563650.2021.1989785

67. Unintentional Drug Poisoning (Overdose) Deaths in New York City in 2021, accessed 19 March 2023

https://www.nyc.gov/assets/doh/downloads/pdf/epi/databrief133.pdf

Excessive vitamin D hormone synthesis and impaired deactivation

68. Adams JS, Liu PT, Chun R, Modlin RL, Hewison M. Vitamin D in defense of the human immune response. Ann N Y Acad Sci. 2007 Nov;1117:94-105. doi: 10.1196/annals.1402.036. Epub 2007 Jul 26. PMID: 17656563.

https://pubmed.ncbi.nlm.nih.gov/17656563/

69. Bischoff-Ferrari HA, Kiel DP, Dawson-Hughes B, Orav JE, Li R, Spiegelman D, Dietrich T, Willett WC. Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J Bone Miner Res. 2009 May;24(5):935-42. doi: 10.1359/jbmr.081242. PMID: 19113911; PMCID: PMC3312737.

https://pubmed.ncbi.nlm.nih.gov/19113911/

70. Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, Seidell JC, Lips P. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab. 2005 Jul;90(7):4119-23. doi: 10.1210/jc.2005-0216. Epub 2005 Apr 26. PMID: 15855256.

https://pubmed.ncbi.nlm.nih.gov/15855256/

Vitamin D and K

71. van Ballegooijen AJ, Pilz S, Tomaschitz A, Grübler MR, Verheyen N. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. Int J Endocrinol. 2017;2017:7454376. doi:10.1155/2017/7454376

https://pubmed.ncbi.nlm.nih.gov/29138634/

72. Kuang X, Liu C, Guo X, Li K, Deng Q, Li D. The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials. Food Funct. 2020;11(4):3280-3297. doi:10.1039/c9fo03063h

https://pubmed.ncbi.nlm.nih.gov/32219282/

73. Brandenburg VM, Schurgers LJ, Kaesler N, et al. Prevention of vasculopathy by vitamin K supplementation: can we turn fiction into fact?. Atherosclerosis. 2015;240(1):10-16. doi:10.1016/j.atherosclerosis.2015.02.040

https://pubmed.ncbi.nlm.nih.gov/25744701/

74. van Ballegooijen AJ, Beulens JW. The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies. Curr Nutr Rep. 2017;6(3):197-205. doi:10.1007/s13668-017-0208-8

https://pubmed.ncbi.nlm.nih.gov/28944098/

75. Haugsgjerd TR, Egeland GM, Nygård OK, et al. Association of dietary vitamin K and risk of coronary heart disease in middle-age adults: the Hordaland Health Study Cohort. BMJ Open. 2020;10(5):e035953. Published 2020 May 21. doi:10.1136/bmjopen-2019-035953

https://pubmed.ncbi.nlm.nih.gov/32444431/

76. Palmer CR, Blekkenhorst LC, Lewis JR, et al. Quantifying dietary vitamin K and its link to cardiovascular health: a narrative review. Food Funct. 2020;11(4):2826-2837. doi:10.1039/c9fo02321f

https://pubmed.ncbi.nlm.nih.gov/32211680/

Vitamin D and magnesium

77. Rosanoff A, Dai Q, Shapses SA. Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? Adv Nutr. 2016 Jan 15;7(1):25-43. doi: 10.3945/an.115.008631. PMID: 26773013; PMCID: PMC4717874.

https://pubmed.ncbi.nlm.nih.gov/26773013/

78. Deng X, Song Y, Manson JE, Signorello LB, Zhang SM, Shrubsole MJ, Ness RM, Seidner DL, Dai Q. Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III. BMC Med. 2013 Aug 27;11:187. doi: 10.1186/1741-7015-11-187. PMID: 23981518; PMCID: PMC3765911.

https://pubmed.ncbi.nlm.nih.gov/23981518/

79. Dai Q, Zhu X, Manson JE, Song Y, Li X, Franke AA, Costello RB, Rosanoff A, Nian H, Fan L, Murff H, Ness RM, Seidner DL, Yu C, Shrubsole MJ. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. Am J Clin Nutr. 2018 Dec 1;108(6):1249-1258. doi: 10.1093/ajcn/nqy274. PMID: 30541089; PMCID: PMC6693398.

https://pubmed.ncbi.nlm.nih.gov/30541089/

80. van Rossum, C. T., Fransen, H. P., Verkaik-Kloosterman, J., Buurma-Rethans, E. J., & Ocké, M. C. (2011). Dutch National Food Consumption Survey 2007-2010: Diet of children and adults aged 7 to 69 years.

https://rivm.openrepository.com/handle/10029/261553

81. Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta. 2000 Apr;294(1-2):1-26. doi: 10.1016/s0009-8981(99)00258-2. PMID: 10727669.

https://pubmed.ncbi.nlm.nih.gov/10727669/

82. Elin RJ. Assessment of magnesium status for diagnosis and therapy. Magnes Res. 2010 Dec;23(4):S194-8. doi: 10.1684/mrh.2010.0213. Epub 2010 Aug 24. PMID: 20736141.

https://pubmed.ncbi.nlm.nih.gov/20736141/

83. Nielsen FH. Magnesium, inflammation, and obesity in chronic disease. Nutr Rev. 2010 Jun;68(6):333-40. doi: 10.1111/j.1753-4887.2010.00293.x. PMID: 20536778.

https://pubmed.ncbi.nlm.nih.gov/20536778/

84. Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev. 2012 Mar;70(3):153-64. doi: 10.1111/j.1753-4887.2011.00465.x. Epub 2012 Feb 15. PMID: 22364157.

https://pubmed.ncbi.nlm.nih.gov/22364157/

85. DiNicolantonio JJ, Liu J, O'Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018 Jul 1;5(2):e000775. doi: 10.1136/openhrt-2018-000775. PMID: 30018772; PMCID: PMC6045762.

https://pubmed.ncbi.nlm.nih.gov/30018772/

86. Magnesium. Voedingscentrum, accessed 21 March 2023

https://www.voedingscentrum.nl/encyclopedie/magnesium.aspx

87. Recommendation on an updated standardization of serum magnesium reference ranges_Rosanoff Eur J Nutr. 2022

https://pubmed.ncbi.nlm.nih.gov/35689124/

Factors determining vitamin D supplement response

88. Reasons for low response to vitamin D. Accessed 21 March 2023

https://vitamindwiki.com/Reasons+for+low+response+to+vitamin+D

Vitamin D interaction with drugs

89. Gröber U, Kisters K. Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731. PMID: 22928072; PMCID: PMC3427195.

https://pubmed.ncbi.nlm.nih.gov/22928072/

Vitamin D supplement use in The Netherlands

90. RIVM. Verandering consumptie voedingsstofsupplementen, accessed 21 March 2023

https://www.wateetnederland.nl/resultaten/veranderingen/verandering-cons...

Vitamin D toxicity not that important

91. What about vitamin D toxicity? Accessed 19 March 2023

http://w.innatechoice.com/utility/printfaq.cfm?id=63C1491E-9564-16E5-1C3...