Dr. J. Flechas, USA. Oxytocine in de behandeling van fibromyalgie en sociale isolatie

Publicaties congres: http://www.rplab.be/fr/publications_proage_2015.cfm

Hertoghe T. Oxytocin & Vasopressin Therapies. Online video course https://hertoghemedicalschool.eu/shop/hormone-therapies/oxytocin-vasopre...

Pruimboom L. Cursus PNI 2e jaar. Natura foundation www.naturafoundation.nl

Lee HJ, Macbeth AH, Pagani JH, Young WS 3rd. Oxytocin: the great facilitator of life. Prog Neurobiol. 2009 Jun;88(2):127-51.

Uvnas-Moberg K, Petersson M. Oxytocin, a mediator of anti-stress, well-being, social interaction, growth and healing. Z Psychosom Med Psychother. 2005;51(1):57-80.

Donaldson ZR, Young LJ. Oxytocin, vasopressin, and the neurogenetics of sociality. Science. 2008 Nov 7;322(5903):900-4.

Yang HP, Wang L, Han L, Wang SC. Nonsocial functions of hypothalamic oxytocin. ISRN Neurosci. 2013 Jul 7;2013:179272. ALLL Zie depressie

Kiss A, Mikkelsen JD. Oxytocin--anatomy and functional assignments: a minireview. Endocr Regul. 2005 Sep;39(3):97-105.

Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001 Apr;81(2):629-83.

Love TM. Oxytocin, motivation and the role of dopamine. Pharmacol Biochem Behav. 2014 Apr;119:49-60.

Beery AK, McEwen LM, MacIsaac JL, Francis DD, Kobor MS. Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Horm Behav. 2016 Jan;77:42-52.

Mazzuca M et al. Newborn Analgesia Mediated by Oxytocin during Delivery. Front Cell Neurosci. 2011 Apr 12;5:3.

Uvnäs-Moberg K, Handlin L, Petersson M. Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation. Front Psychol. 2015 Jan 12;5:1529.

Cox EQ, Stuebe A, Pearson B, Grewen K, Rubinow D, Meltzer-Brody S. Oxytocin and HPA stress axis reactivity in postpartum women. Psychoneuroendocrinology. 2015 May;55:164-72.

Acevedo-Rodriguez A, Mani SK, Handa RJ. Oxytocin and Estrogen Receptor β in the Brain: An Overview. Front Endocrinol (Lausanne).2015 Oct 15;6:160.

Donaldson ZR, Young LJ. Oxytocin, vasopressin, and the neurogenetics of sociality. Science. 2008 Nov 7;322(5903):900-4.

Paquin J et al. Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes.

Costa A et al. Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis. Eur J Transl Myol. 2014 Sep 22;24(3):3790.

Krueger F et al. Oxytocin receptor genetic variation promotes human trust behavior. Front Hum Neurosci. 2012 Feb 2;6:4.

Jankowski M, Gonzalez-Reyes A, Noiseux N, Gutkowska J. Oxytocin in the heart regeneration. Recent Pat Cardiovasc Drug Discov. 2012 Aug;7(2):81-7

Gutkowska J, Jankowski M, Antunes-Rodrigues J. The role of oxytocin in cardiovascular regulation. Braz J Med Biol Res. 2014 Feb;47(3):206-14.

Massey SH et al. Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity. Arch Womens Ment Health 2016 Mar 8. [Epub ahead of print]

Massey SH et al. Plasma oxytocin concentration and depressive symptoms : a review of the current evidence and directions for future research. Depress Anxiety 2016; Jan 12. doi: 10.1002/da.22467. [Epub ahead of print] (man en vrouw)

McQuaid RJ et al. Making room for oxytocin in understanding depression. Neurosci Biobehav Rev. 2014 Sep;45:305-22.

McInnis OA et al. The moderating role of an oxytocin receptor gene polymorphism in the relation between unsupportive social interactions and coping profiles: implications for depression. Front Psychol 2015 Aug 11;6:1133.

Scantamburloa G et al. Plasma oxytocinlevels and anxiety in patients with major depression. Psychoneuroendocrinology 2007; 32, 407–410

Kudwa AE, McGivern RF, Handa RJ. Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats. Physiol Behav. 2014 Apr 22;129:287-96.

Morton GJ et al. Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E134-44.

Weiser MJ, Foradori CD, Handa RJ. Estrogen receptor beta activation prevents glucocorticoid receptor-dependent effects of the central nucleus of the amygdala on behavior and neuroendocrine function. Brain Res. 2010 Jun 8;1336:78-88

Rash JA et al. Oxytocin and pain: a systematic review and synthesis of findings. Clin J Pain. 2014 May;30(5):453-62.

Goodin BR, Ness TJ, Robbins MT. Oxytocin - a multifunctional analgesic for chronic deep tissue pain. Curr Pharm Des. 2015;21(7):906-13.

Tracy LM, Georgiou-Karistianis N, Gibson SJ, Giummarra MJ. Oxytocin and the modulation of pain experience: Implications for chronic pain management. Neurosci Biobehav Rev. 2015 Aug;55:53-67.

Goodin BR, Ness T, Robbins MT. Oxytocin - a multifunctional analgesic for chronic deep tissue pain. Curr Pharm Des. 2015;21(7):906-13.

Rash JA, Aguirre -Camacho A, Campbell TS. Oxytocin and pain: a systematic review and synthesis of findings. Clin J Pain. 2014 May;30(5):453-62.

Goodin BR et al. Intranasal Oxytocin Administration is Associated with Enhanced Endogenous Pain Inhibition and Reduced Negative Mood States. Clin J Pain. 2014 Nov 3. [Epub ahead of print]

Tracy LM eet al. Oxytocin and the modulation of pain experience: Implications for chronic pain management. Neurosci Biobehav Rev. 2015 Aug;55:53-67.

Louvel D et al. Oxytocin increases tresholds of colonic visceral perception in patients with irritable bowel syndrome. Gut 1996 39(5):741-47.

Yang X et al. Oxytocin decreases colonic motility of cold water stressed rats via oxytocin receptors. World J Gastroenterol. 2014 Aug 21;20(31):10886-94.

Alfven G. Plasma oxytocin in children with recurrent abdominal pain. J Pediatr Gastroenterol Nutr 2004; 38(5):513-7

Yang J. Intrathecal administration of Oxytocin inuces Analgesia in Low Back Pain Involving the Endogenous Opiate Peptide System. Spine 1994; 19:86771.

Phillips WJ. Relief of acute migraine with intravenous oxytocin. J Pain Palliat Care Pharmacother. 2006; 20(3):25-8.

Madrazo I et al. Intraventricular somatostatin-14, arginine vasopressin, and oxytocin: analgesic effect in a patient with intractable cancer pain.Appl Neurophysiol 1987;50(1-6):427-31.

Eliava M et al. A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing. Neuron 2016 Mar 16;89(6):1291-304.

Bulut EC et al. Treatment with oestrogen-receptor agonists or oxytocin in conjunction with exercise protects against post-menopausal myocardial infarction in rats. Exp Physiol. 2016 Mar 9. doi: 10.1113/EP085708. [Epub ahead of print]

Elabd C et al. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. 2014; 5:4082 | DOI: 10.1038/ncomms5082 | www.nature.com/naturecommunications

Colaianni G, Sun L, Zaidi M, Zallone A. Oxytocin and bone. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R970-7.

Elabd C et al. OxytocinControls Differentiation of Human MesenchymalStem Cells and Reverses Osteoporosis. Stem Cells 2008; 26(9):2399-407.

Beranger GE et al. Oxytocin reverses osteoporosis in a sex-dependent manner. Front Endocrinol (Lausanne). 2015 May 19;6:81.

Colaianni G et al. The "love hormone" oxytocin regulates the loss and gain of the fat-bone relationship. Front Endocrinol (Lausanne). 2015 May 18;6:79.

Colaianni Get al. The oxytocin-bone axis. J Neuroendocrinol. 2014 Feb;26(2):53-7.

Caldwell HK, Albers HE. Oxytocin, Vasopressin, and the Motivational Forces that Drive Social Behaviors. Curr Top Behav Neurosci. 2015 Oct 15. [Epub ahead of print] neuropsy

Olff M et al. The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences. Psychoneuroendocrinology 2013; 38:1883-94.

Kirsch P. Oxytocin in the socioemotional brain: implications for psychiatric disorders. Dialogues Clin Neurosci. 2015 Dec;17(4):463-76.

Ebner NC et al. Oxytocin and socioemotional aging: Current knowledge and future trends. Front Hum Neurosci. 2013 Aug 28;7:487.

Ebner NC et al. Oxytocin modulates meta-mood as a function of age and sex. Front Aging Neurosci. 2015 Sep 10;7:175.

Aspé-Sánchez M, Moreno M, Rivera MI, Rossi A, Ewer J. Oxytocin and Vasopressin Receptor Gene Polymorphisms: Role in Social and Psychiatric Traits. Front Neurosci. 2016 Jan 28;9:510.

Harony H, Wagner S. The contribution of oxytocin and vasopressin to mammalian social behavior: potential role in autism spectrum disorder. Neurosignals. 2010;18(2):82-97.

Pruimboom L. Fibromialgie, Een psycho-neuro-immuno-endocrinologische aandoening. Arts en Apotheek, 2000 oktober; 3:2-13.

Jin H et al. Topical review: the enigma of fibromyalgia. J Oral Facial Pain Headache. 2014 Spring;28(2):107-18

Neumann L, Buskila D. Epidemiology of fibromyalgia. Curr Pain Headache Rep. 2003; 7:362–8.

Annemans L, Le Lay K, Taieb C. Societal and patient burden of fibromyalgia syndrome. Pharmacoeconomics. 2009; 27:547–59.

White LA, Robinson RL, Yu AP et al. Comparison of health care use and costs in newly diagnosed and established patients with fibromyalgia. J Pain. 2009; 10:976–83.

Annemans L, Wessely S, Spaepen E et al. Health economic consequences related to the diagnosis of fibromyalgia syndrome. Arthritis Rheum. 2008; 58:895–902.

Harth M. Cursing the darkness: Reactions to fibromyalgia Pain Res Manag. 2013 Mar-Apr; 18(2): 64–66.

Arnold LM et al. Fibromyalgia and Chronic Pain Syndromes: A White Paper Detailing Current Challenges in the Field. Clin Pain 2016, 28 march

Nüesch E et al. Comparative efficacy of pharmacological and non-pharmacological interventions in fibromyalgia syndrome: network meta-analysis. Ann Rheum Dis. 2013 Jun;72(6):955-62

Fibromyalgia: poorly understood; treatments are disappointing. Prescrire Int. 2009 Aug;18(102):169-73.

Kindler LL et al. Central sensitivity syndromes: mounting pathophysiologic evidence to link fibromyalgia with other common chronic pain disorders. Pain Manag Nurs. 2011 Mar;12(1):15-24.

Pruimboom L. Script cursus Orthomoleculaire Therapeut module 3: Chronische Pijn. 2000

Jason LA. Are Myalgic Encephalomyelitis and Chronic Fatigue Syndrome different illnesses? A preliminary analysis. J Health Psychol. 2015 21(1):3-15.

Kurland JE1, Coyle WJ, Winkler A, Zable E. Jason LA. Prevalence of irritable bowel syndrome and depression in fibromyalgia. Dig Dis Sci. 2006 Mar;51(3):454-60.

Anderberg UM, Uvnas-Moberg K. Plasma oxytocinlevels in female fibromyalgia syndrome. Z Rheumatol. 2000 Dec;59(6):373-9.

Flechas JD. Alternative Treatment of Fibromyalgia Using the Oxytocin-Hormonal-Nutrient Protocol to Increase Nitric Oxide. Privately published monograph, January 1998. http://helpmythyroid.com/abstract1.html

Flechas J. The potential of oxytocin, nitric oxide, and iodine. Altern Ther Health Med. 2013 Jul-Aug;19(4):50-6

Mameli S et al. Oxytocin nasal spray in fibromyalgic patients. Rheumatol Int. 2014 Aug;34(8):1047-52

Kumsta R, Heinrichs M. Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system. Curr Opin Neurobiol 2013 Feb;23(1):11-6.

Macdonald K, Macdonald TM. The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans. Harv Rev Psychiatry. 2010 Jan-Feb;18(1):1-21

Donaldson ZR, Young LJ. Oxytocin, vasopressin, and the neurogenetics of sociality. Science. 2008 Nov 7;322(5903):900-4

Striepens N et al. Prosocial effects of oxytocin and clinical evidence for its therapeutic potential. Front Neuroendocrinol. 2011 Oct;32(4):426-50.

Mitre M et al. A Distributed Network for Social Cognition Enriched for Oxytocin Receptors. J Neurosci. 2016 Feb 24;36(8):2517-35.

Ebstein RP et al. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm Behav. 2012 Mar;61(3):359-79.

Huang H, Papaleo F. Genetic modulation of oxytocin's effects in social functioning. Ann Transl Med. 2015 Dec;3(22):348.

Krueger F et al. Oxytocin receptor genetic variation promotes human trust behavior. Front Hum Neurosci. 2012 Feb 2;6:4.

Heinrichs M, von Dawans B. Oxytocin, vasopressin, and human social behavior. Frontiers in Neuroendocrinology 2009; 30:548–557

Inoue H et al. Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults. Biol Psychiatry 2010; 68(11):1066–1072.

Marazziti D, Catena Dell'osso M. The role of oxytocin in neuropsychiatric disorders. Curr Med Chem. 2008;15(7):698-704.

Francis SM et al. Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders. Brain Res. 2014 Sep 11;1580:199-218

Kirsch P. Oxytocin in the socioemotional brain: implications for psychiatric disorders. Dialogues Clin Neurosci. 2015 Dec;17(4):463-76.

Kanat M, Heinrichs M, Domes G. Oxytocin and the social brain: neural mechanisms and perspectives in human research. Brain Res. 2014 Sep 11;1580:160-71.

Romano A et al. From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders. Front Neurosci. 2016 Jan 12;9:497.

Modahl C et al. Plasma OxytocinLevels in Autistic Children. Biol Psychiatry 1998; 271 (43):270-277.

Green LA, Morris M. Oxytocin and Autistic Disorder: Alterations in Peptide Forms. Biol Psychiatry 2001;50:609–613.

Wermter AK et al. Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):629-39.

Chen FS et al. Genetic modulation of oxytocin sensitivity: a pharmacogenetic approach. Transl Psychiatry. 2015 Oct 27;5:e664.

Lerer E et al. Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. Mol Psychiatry. 2008 Oct;13(10):980-8.

Kim et al. Neuronal mechanisms and circuits underlying repetitive behaviours in mouse models of autism spectrum disorder. Behav Brain Funct 2016; 12(1):3.

Lukas M, Neumann ID. Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders. Behav Brain Res. 2013 Aug 15;251:85-94.

Munesue T et al. Oxytocin for Male Subjects with Autism Spectrum Disorder and Comorbid Intellectual Disabilities: A Randomized Pilot Study. Front Psychiatry. 2016 Jan 21;7:2.

Peñagarikano O. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Sci Transl Med 2015; 7:271ra8

Aoki Y et al. Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism. Brain. 2014 Nov;137(Pt 11):3073-86.

Penagarikano O. New Therapeutic Options for autism spectrum disorder: experimental evidences. Exp Neurobiol 2015; 24(4):301-311.

Anagnostou E et al. Intranasal oxytocin in the treatment of autism spectrum disorders: a review of literature and early safety and efficacy data in youth. Brain Res. 2014 Sep 11;1580:188-98.

Preti A et al. Oxytocin and autism: a systematic review of randomized controlled trials. J Child Adolesc Psychopharmacol. 2014 Mar;24(2):54-68.

Peñagarikano O. New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences. Exp Neurobiol. 2015 Dec;24(4):301-11.

Bartz JA, Hollander E. Oxytocin and experimental therapeutics in autism spectrum disorders. Prog Brain Res. 2008;170:451-62.

Lee SY et al. Is Oxytocin Application for Autism Spectrum Disorder Evidence-Based? Exp Neurobiol. 2015 Dec;24(4):312-24.

Anagnostou E et al. Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial. Mol Autism. 2012; 5;3(1):16.

Peñagarikano O. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Sci Transl Med 2015; 7:271ra8

Taylor AE et al. Oxytocin treatment in pediatric populations. Front behav Neurosci 2014; 16(8):360.

Viero C et al. REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy. CNS Neurosci Ther 2010 Oct;16(5):e138-56.

Ebner NC et al. Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study. PLoS One. 2015 Dec 15;10(12):e0145104.

Taylor AE, Lee HE, Buisman-Pijlman FT. Oxytocin treatment in pediatric populations. Front Behav Neurosci. 2014 Oct 16;8:360.

Zik JB, Roberts DL. The many faces of oxytocin: implications for psychiatry. Psychiatry Res. 2015 Mar 30;226(1):31-7.

Olff M et al. The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences. Psychoneuroendocrinology. 2013 Sep;38(9):1883-94.

Evans SL, Dal Monte O, Noble P, Averbeck BB. Intranasal oxytocin effects on social cognition: a critique. Brain Res. 2014 Sep 11;1580:69-77.

Ishunina TA, Swaab DF. Neurohypophyseal peptides in aging and Alzheimer's disease. Ageing Res Rev 2002; 1(3):537-58.4

Hertoghe T. Oxytocin & Vasopressin Therapies. www.hertoghemedicalschool.eu

Hertoghe T. Passion, Sex and Long Life: The incredible Oxytocin Adventure. www.hertoghemedicalschool.eu