Fijnstof: onzichtbaar gezondheidsgevaar

Luchtvervuiling is een wereldwijd probleem. Naar schatting 92% van alle mensen leeft in gebieden waar luchtvervuiling (fijnstof, gassen) de norm van de Wereldgezondheidsorganisatie voor de luchtkwaliteit overschrijdt.1 Wetenschappers zijn zeer bezorgd over de schadelijke effecten van fijnstof, in de lucht zwevende deeltjes (Particulate Matter, particle pollution) met een maximale diameter van 10 micrometer (PM10). Wat kunnen de gevolgen voor de gezondheid zijn van blootstelling aan fijnstof en welke nutriënten beperken de toxische effecten?

Beste bezoeker, u heeft geen toegang.

Enkel (web)abonnees hebben toegang tot tijdschriftartikelen. Het webabonnement is nog in de maak.

U kunt zich wel alvast (gratis) registreren en tal van andere webartikelen raadplegen!

Auteur

Selma Timmer

Trefwoorden:

Verschenen in

Referenties

  1. World Health Organization (September 27, 2016) WHO releases country estimates on air pollution exposure and health impact. Press release. http://www.who.int/en/news-room/detail/27-09-2016-who-releases-country-e...
  2. Liu HY et al. A review of airborne particulate matter effects on young children’s respiratory symptoms and diseases. Atmosphere 2018;9:150.
  3. Pope CA et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. Jama. 2002;287(9):1132-41.
  4. Garshick E. Effects of short- and long-term exposures to ambient air pollution on COPD. Eur Respir J. 2014;44(3):558-61.
  5. Brook RD. Cardiovascular effects of air pollution. Clin Sci (Lond). 2008;115(6):175-87.
  6. Peters A. Particulate matter and heart disease: evidence from epidemiological studies. Toxicol Appl Pharmacol. 2005;207(2 Suppl):477-82.
  7. Pope CA et al. Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation. Circ Res. 2016;119(11):1204-14.
  8. Brook RD et al. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation. 2010;121(21):2331-78.
  9. Consonni D et al. Outdoor particulate matter (PM10) exposure and lung cancer risk in the EAGLE study. PLoS One. 2018;13(9):e0203539.
  10. Whyand T et al. Pollution and respiratory disease: can diet or supplements help? A review. Respir Res. 2018;19(1):79.
  11. Park SK et al. HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction. Circulation. 2006;114(25):2798-805.
  12. Brook RD et al. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation. 2010;121(21):2331-78.
  13. Holguin F et al. Air pollution and heart rate variability among the elderly in Mexico City. Epidemiology. 2003;14(5):521-7.
  14. Wolf K et al. Association between long-term exposure to air pollution and biomarkers related to insulin resistance, subclinical inflammation, and adipokines. Diabetes. 2016;65(11):3314-26.
  15. Zeka A et al. Inflammatory markers and particulate air pollution: characterizing the pathway to disease. Int J Epidemiol. 2006;35(5):1347-54.
  16. Poljsak B et al. The protective role of antioxidants in the defence against ROS/RNS-mediated environmental pollution. Oxid Med Cell Longev. 2014;2014:671539.
  17. Nel AE et al. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med. 2001;7(1):20-6.
  18. Bai Y et al. Fine particulate matter air pollution and atherosclerosis: mechanistic insights. Biochim Biophys Acta. 2016;1860(12):2863-8.
  19. Shin J et al. Long-term exposure to ambient air pollutants and mental health status: A nationwide population-based cross-sectional study. PLoS ONE 2018,13(4):e0195607.
  20. Magnani ND et al. Skin damage mechanisms related to airborne particulate matter exposure. Toxicol Sci. 2016;149(1):227-36.
  21. He D et al. Association between particulate matter 2.5 and diabetes mellitus: A meta-analysis of cohort studies. J Diabetes Investig. 2017;8(5):687-696.
  22. Gawda A et al. Air pollution, oxidative stress, and exacerbation of autoimmune diseases. Cent Eur J Immunol. 2017; 42(3): 305-312.
  23. Sun G et al. Association between air pollution and the development of rheumatic disease: a systematic review. Int J Rheumatol. 2016;2016:5356307.
  24. Brook RD et al. Long-term fine particulate matter exposure and mortality from diabetes in Canada. Diabetes Care. 2013;36:3313-20.
  25. Ailshire JA et al. Fine particulate matter air pollution and cognitive function among U.S. older adults. J Gerontol B Psychol Sci Soc Sci. 2015;70(2):322-8.
  26. Hoek G et al. Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet. 2002;360(9341):1203-9.
  27. Pope CA et al. Fine-particulate air pollution and life expectancy in the United States. N Engl J Med. 2009;360(4):376-86.
  28. Correia AW et al. Effect of air pollution control on life expectancy in the United States: an analysis of 545 U.S. counties for the period from 2000 to 2007. Epidemiol. 2013;24(1):23-31.
  29. Zhong J et al. B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. Proc Natl Acad Sci USA. 2017;114(13):3503-3508.
  30. Tong H. Dietary and pharmacological intervention to mitigate the cardiopulmonary effects of air pollution toxicity. Biochim Biophys Acta. 2016;1860(12):2891-8.
  31. Li XY et al. Protection against fine particle-induced pulmonary and systemic inflammation by omega-3 polyunsaturated fatty acids. Biochim Biophys Acta Gen Subj. 2017;1861(3):577-584.
  32. Romieu I et al. The effect of supplementation with omega-3 polyunsaturated fatty acids on markers of oxidative stress in elderly exposed to PM(2.5). Environ Health Perspect. 2008;116(9):1237-42.
  33. Tong H et al. Omega-3 fatty acid supplementation appears to attenuate particulate air pollution-induced cardiac effects and lipid changes in healthy middle-aged adults. Environ Health Perspect. 2012;120(7):952-7.
  34. Romleu I et al. Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter. Am J Respir Crit Care Med. 2005;172:1534-1540.
  35. Sriram J et al. Mitigation of particulate matter-induced inflammation and vasoactivity in human vascular endothelial cells by omega-3 polyunsaturated fatty acids. Int J Environ Res Public Health. 2018;15(10):2293.
  36. Bo L et al. Effect of vitamin E and omega-3 fatty acids on protecting ambient PM2.5-induced inflammatory response and oxidative stress in vascular endothelial cells. PLoS ONE 11(3): e0152216.
  37. Baccarelli A et al. Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation. 2008;117(14):1802-9.
  38. Zhong J et al. B-vitamin supplementation mitigates effects of fine particles on cardiac autonomic dysfunction and inflammation: a pilot human intervention trial. Sci Rep. 2017 Apr 3;7:45322.
  39. Park SY et al. Traffic-related particles are associated with elevated homocysteine. Am J Respir Crit Care Med. 2008;178:283-289.
  40. Ren C et al. Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution. Epidemiology. 2010;21(2):198-206.
  41. Turner MC et al. Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers. Am J Respir Crit Care Med. 2011;184:1374-81.
  42. Pope CA et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 2002;287:1132-41.
  43. Zhang Z et al. The effect of curcumin on human bronchial epithelial cells exposed to fine particulate matter: a predictive analysis. Molecules 2012;17:12406-26.
  44. Shi J et al. Curcumin pretreatment protects against PM2.5‑induced oxidized low‑density lipoprotein‑mediated oxidative stress and inflammation in human microvascular endothelial cells. Mol Med Rep. 2017;16(3):2588-2594.
  45. Nemmar A et al. Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice. PLoS One. 2012;7(6):e39554.
  46. Zeng X et al. The protective effects of selenium supplementation on ambient PM2.5-induced cardiovascular injury in rats. Environ Sci Pollut Res Int. 2018;25(22):22153-62.
  47. Liu J et al. Investigation of selenium pretreatment in the attenuation of lung injury in rats induced by fine particulate matters. Environ Sci Pollut Res. 2017;24:4008-4017.
  48. Tong H et al. Dietary supplementation with olive oil or fish oil and vascular effects of concentrated ambient particulate matter exposure in human volunteers. Environ Health Perspect. 2015;123(11):1173-9.
  49. Riedl MA et al. Oral sulforaphane increases phase II antioxidant enzymes in the human upper airway. Clin Immunol. 2009;130(3):244-51.
  50. Verhagen H et al. Reduction of oxidative DNA-damage in humans by brussels sprouts. Carcinogenesis. 1995;16(4):969-70.
  51. Heber D et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014;5(1):35-41.
  52. Egner PA et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila). 2014;7(8):813-23.
  53. James D et al. Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced glucoraphan in broccoli. Nutr Rev. 2012;70(11):654-65.
  54. Carlsten C et al. Anti-oxidant N-acetylcysteine diminishes diesel exhaust-induced increased airway responsiveness in person with airway hyper-reactivity. Toxicol Sci. 2014;139:479-87.
  55. Yang GZ et al. Epigallocatechin-3-gallate protects HUVECs from PM2.5-induced oxidative stress injury by activating critical antioxidant pathways. Molecules. 2015;20(4):6626-39