Een nieuw behandelingsmodel voor niet-infectieuze ziekten

Chronische niet-infectieuze ziekten (CNCD: chronic
non-communicable diseases), van hart- en vaatziekten en
diabetes, over depressie, auto-immuunziekten en alzheimer en
parkinson enzovoort zijn verantwoordelijk voor 35 van de 52
miljoen jaarlijkse overlijdens wereldwijd. Daarnaast lijden
ontelbare mensen aan chronische pijnsyndromen en vermoeidheid. Al
deze ‘ziekten’ hebben één gemeenschappelijke, alomtegenwoordige
oorzaak: chronische laaggradige inflammatie (CLGI) of
‘metaflammatie’.

Beste bezoeker, u heeft geen toegang.

Enkel (web)abonnees hebben toegang tot tijdschriftartikelen. Het webabonnement is nog in de maak.

U kunt zich wel alvast (gratis) registreren en tal van andere webartikelen raadplegen!

Auteur

Marleen Nys
Leo Pruimboom

Trefwoorden:

Figuren

Verschenen in

Referenties

  1. Bosma-den Boer MM, van Wetten ML, Pruimboom L. Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering. Nutr Metab (Lond) 2012,9:32.

  2. Muskiet FAJ, Muskiet HAM. Chronische systemische lagegraadontsteking. AT&A 2012; 1:10-16.

  3. Pruimboom L. Insulineresistentie, een pandemisch problem. AT&A 2011; 2:30-36.

  4. Pruimboom et al. When the immune system overrides the selfish brain. 2013 [in press]. Zie: Dementie, Alzheimer, neurodegeneratie, … Als het immuunsysteem het overneemt van de hersenen… AT&A 2012; 3:44-47

  5. Antolin MF, Jenkins KP, Bergstrom CT, Crespi BJ et al.Evolution and medicine in undergraduate education: a prescription for all biology students. Evolution 2012; 66:1991-2006.

  6. Becker B, Kronenberg F, Kielstein JT, Haller H et al.Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study. J Am Soc Nephrol 2005; 16, 1091-8.

  7. Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol 2009;5:374-381.

  8. Pawate S, Sriram S. The role of infections in the pathogenesis and course of multiple sclerosis. Ann Indian Acad Neurol 2010; 13:80-86.

  9. Nys M. Het Ontstekingssyndroom. “The Inflammation Syndrome aan de basis van degeneratieziekten. AT&A 2006; 4:5055.

  10. Peters A. The energy request of inflammation. Endocrinology2006; 147:4550-4552.

  11. Pruimboom, L. Physical inactivity is a disease synonymous for a non-permissive brain disorder. Med Hypotheses 2011; 77:708-713.

  12. Dhabhar FS, Malarkey WB, Neri E, McEwen BS. Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones--Curt Richter Award winner. Psychoneuroendocrinology 2012; 37, 1345-1368.

  13. O'Keefe JH, Bell DS. Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol 2007; 100:899-904.

  14. Straub RH, Cutolo M, Buttgereit F, Pongratz G. Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases. J Intern Med 2010; 267:543-560.

  15. Raison CL, Miller AH. The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D). Mol Psychiatry2013; 18:15-37.

  16. Hancock AM, Witonsky DB, Alkorta-Aranburu G, Beall CM et al. Adaptations to climate-mediated selective pressures in humans. PLoS 2011; Genet 7, e1001375.

  17. Di Cesare, M., Khang, Y. H., Asaria, P., Blakely, T., et al.Inequalities in non-communicable diseases and effective responses. Lancet 381, 585-597 (2013).

  18. Dinan, T. G. & Cryan, J. F. Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology. Psychoneuroendocrinology 37, 1369-1378 (2012).

  19. Klop B, Proctor SD, Mamo JC, Botham KM, Castro Cabezas M. Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases. Int J Vasc Med2012; 947417.

  20. Lieberman B. Details of being human. Nature 2008; 454, 21-23.

  21. Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev Mol Med 2011; 13:e30.

  22. Molnar-Kimber KL, Kimber CT. Each type of cause that initiates rheumatoid arthritis or RA flares differentially affects the response to therapy. Med Hypotheses 2012; 78:23-129.

  23. Hancock AM, Witonsky DB, Ehler E, Alkorta-Aranburu G et al. Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency. Proc Natl Acad Sci USA 2010;107:Suppl 2, 8924-8930.

  24. Øverli Ø. Preface: plasticity and diversity in behavior and brain function--important raw material for natural selection? Brain Behav Evol2007; 70:215-217.

  25. Södersten P, Nergårdh R, Bergh C, Zandian M, Scheurink A. Behavioral neuroendocrinology and treatment of anorexia nervosa. Front Neuroendocrinol 2008;29, 445-462.

  26. Sparks Stein P, Steffen MJ, Smith C, Jicha G et al.Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease. Alzheimers Dement2012; 8:196-203 .

  27. Hou YC, Chiu WC, Yeh CL, Yeh SL. Glutamine modulates lipopolysaccharide-induced activation of NF-κB via the Akt/mTOR pathway in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2012; 302:L174-L183.

  28. Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A. Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. J Immunol2010; 184:4185-4195.

  29. Schaller, M. The behavioural immune system and the psychology of human sociality. Philos Trans R Soc Lond B Biol Sci366, 3418-3426 (2011).

  30. O'Bleness M, Searles VB, Varki A, Gagneux P, Sikela, JM. Evolution of genetic and genomic features unique to the human lineage. Nat Rev Genet 2012; 13:853-866.

 

  1. Banda K, Gregg CJ, Chow R, Varki NM, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: mechanisms underlying gastrointestinal incorporation of the non-human sialic acid xeno-autoantigen N-glycolylneuraminic acid. J Biol Chem 2012; 287, 28852-64.

  2. Bergfeld AK, Pearce OM, Diaz SL, Pham T, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. J Biol Chem 287, 28865-28881 (2012).

  3. Bergfeld AK, Pearce OM, Diaz SL, Lawrence R et al. Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine. J Biol Chem2012; 287, 28898-916.

  4. Bode, L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology2012; 22:1147-1162.

  5. Davies LR, Pearce OM, Tessier MB, Assar S et al. Metabolism of vertebrate amino sugars with N-glycolyl groups: resistance of α2-8-linked N-glycolylneuraminic acid to enzymatic cleavage. J Biol Chem 2012; 287:28917-31.

  6. Nguyen DH, Hurtado-Ziola N, Gagneux P, Varki A. Loss of Siglec expression on T lymphocytes during human evolution. Proc Natl Acad Sci USA 2006; 103:7765-7770 .

  7. Padler-Karavani V, Yu H, Cao H, Chokhawala H et al.Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease. Glycobiology 2008; 18:818-830.

  8. Severance EG, Gressitt KL, Halling M, Stallings CR et al. Complement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia. Neurobiol Dis 2012; 48:447-453.

  9. Siala M, Gdoura R, Fourati H, Rihl M et al.Broad-range PCR, cloning and sequencing of the full 16S rRNA gene for detection of bacterial DNA in synovial fluid samples of Tunisian patients with reactive and undifferentiated arthritis. Arthritis Res Ther 2009; 11:R102.

  10. Tangvoranuntakul P, Gagneux P, Diaz S, Bardor M, et al.Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc Natl Acad Sci U S A 2003; 100:12045-50.

  11. ten Freyhaus H., Calay ES, Yalcin A, Vallerie SN, et al. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab 2012; 16:81-89.

  12. Varki A. Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them. Glycobiology 2011; 21:1121-1124.

  13. Varki A, Gagneux P. Multifarious roles of sialic acids in immunity. Ann N Y Acad Sci 2012; 1253:16-36.

  14. Wells, J. C. The evolution of human adiposity and obesity: where did it all go wrong? Dis Model Mech 2012; 5:595-607.

  15. Strawbridge J. Physical Activity Reduces the Risk of Subsequent Depression for Older Adults. Am J Epidemiol2002; 156, 328-334.

  16. Reilly SM et al. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar;19(3):313-21.

  17. Koch L. Obesity: Teaching an old drug new tricks--amlexanox targets inflammation to improve metabolic dysfunction. Nat Rev Endocrinol. 2013 Apr;9(4):185.

  18. Calay ES, Hotamisligil GS. Turning off the inflammatory, but not the metabolic, flames. Nat Med. 2013 Mar;19(3):265-7.

  19. Crunkhorn S. Metabolic disorders: Breaking the links between inflammation and diabetes. Nat Rev Drug Discov. 2013 Apr;12(4):261.

  20. Yang YC, Lii CK, Wei YL, Li CC et al. Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways. J Nutr Biochem2013; 24:204-212.

  21. Slutsky I, Abumaria N, Wu LJ, Huang C et al. Enhancement of learning and memory by elevating brain magnesium. Neuron 2010;65:165-177.

  22. Abumaria N, Yin B, Zhang L, Li XY et al.Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J Neurosci 2011; 31:14871-14881.

  23. Eby GA, Eby KL. Magnesium for treatment-resistant depression: a review and hypothesis. Med Hypotheses2010; 74:649-660.

Gerelateerde artikelen

Mediterrane voeding beschermt tegen de ontwikkeling van diabetes
Naturopathie boekt succes bij diabetici
Hersenontstekingen afweren doet diabetes bezweren
Zuivel: gezond en ongezond?
Dementie is voor een derde een leefstijlziekte